Sex differences in statin response in hypercholesterolemic (Apoe knockout) Four Core Genotypes mice.. Sex differences in statin response in hypercholesterolemic (Apoe knockout) Four Core Genotypes mice.

RNA-sequening of livers from Apoe knockout Four Core Genotypes mice (XX ovaries, XX testes, XY ovaries, XY testes) fed either chow diet or chow diet + simvastatin (0.1g/kg) for 8 weeks. Overall design: Apoe knockout Four Core Genotypes mice were fed either chow diet (Research Diets D1001) or chow diet + simvastatin (0.1g/kg) for 8 weeks. RNA was isolated from liver tissue and prepared for total RNA sequencing.