Data from paper: Synaptic resilience is associated with maintained cognition during ageing

It remains unclear why age increases risk of Alzheimer’s disease and why some people experience age-related cognitive decline in the absence of dementia. Here we test the hypothesis that resilience to molecular changes in synapses contribute to healthy cognitive ageing. We examined post-mortem brain from people in mid-life (n=15), healthy ageing with either maintained cognition (n=9) or lifetime cognitive decline (n=8), and Alzheimer’s disease (n=13). Synapses were examined with high resolution imaging, proteomics, and RNA sequencing. Stem cell-derived neurons were challenged with Alzheimer’s brain homogenate. Synaptic pathology increased, and expression of genes involved in synaptic signalling decreased between mid-life, healthy ageing and Alzheimer’s. In contrast, brain tissue and neurons from people with maintained cognition during ageing exhibited decreases in synaptic signalling genes compared to people with cognitive decline. Efficient synaptic networks without pathological protein accumulation may contribute to maintained cognition during ageing. This dataset includes all analysed spreadsheets and statistical analysis macros from the study for further use. ## Image data ## For raw images associated with the study, which are stored in Edinburgh DataVault, please contact the authors for download links. ## Associated publications ## * King, D., Holt, K., Toombs, J., He, X., Dando, O., Okely, J., Rose, J., Gunn, C., Correia, A., Montero, C., Tulloch, J., Lamont, D., Taylor, A., Harris, S., Redmond, P., Cox, S. R., Henstridge, C., Deary, I. J., Smith, C., & Spires-Jones, T. (2022). Synaptic resilience is associated with maintained cognition during ageing. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. https://doi.org/10.1002/alz.12894 * Declan King, Kris Holt, Jamie Toombs, Xin He, Owen Dando, J. A. Okely, Jamie Rose, Ciaran Gunn, Adele Correia, Carmen Montero, Jane Tulloch, Douglas Lamont, Adele M Taylor, Sarah E Harris, Paul Redmond, Simon R Cox, Christopher M Henstridge, Ian J Deary, Colin Smith, Tara L Spires-Jones. medRxiv 2022.05.04.22274679; doi: https://doi.org/10.1101/2022.05.04.22274679 This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice.