miRNA-99 family diverges physiological cardiac hypertrophy to pathological cardiac hypertrophy

Conclusions: The results proved Egr-1 mediated regulation of miR-99 family determines the uniqueness of pathological and physiological hypertrophy. Upregulated miR-99 expression during pathological hypertrophy suggests that it can be a valuable diagnostic marker and potential therapeutic target for cardiac hypertrophy and heart failure.研究结论：本研究结果证实，早期生长反应蛋白1（Egr-1）介导的miR-99家族调控作用，决定了病理性与生理性心肌肥厚的特异性差异。病理性心肌肥厚过程中miR-99的表达上调，表明其可作为心肌肥厚与心力衰竭极具价值的诊断标志物及潜在治疗靶点。