Clinical and virological parameters of HIV-infected individuals.

aEAP, Expanded Access Program for the use of maraviroc at multiple centers; Allegro, multicenter study to assess the prevalence of R5 HIV-1 variants in Spain [39].bVirologic response at week 12 following a maraviroc-based antiretroviral regimen, defined as a decrease in plasma viral load below 400 copies/ml. End of study, HIV-infected individuals did not enter the study following the detection of non-R5 viruses at baseline (see below); n.a., not available.CHIV-1 coreceptor tropism was determined at baseline using a phenotypic test, i.e., the original Trofile™ assay (Monogram Biosciences) [11]. R5, CCR5-tropic virus; D/M, dual mixed, that is a combination of CCR5- and CXCR4-tropic viruses; n.d., not determined.