ALKBH5-mediated m6A modification of 5-HT3A mRNA in primary sensory neurons promotes neuropathic pain behaviors

trigeminal-mediated nerve injury increases the expression of the m6A demethylase ALKBH5 in the injured TG, which elevates the level of 5-HT3A in TG and induces pain-related behaviors.三叉神经介导的神经损伤可上调损伤三叉神经节（Trigeminal Ganglion，TG）内m6A去甲基化酶ALKBH5的表达，该变化可升高三叉神经节内5-羟色胺3A型受体（5-HT3A）的表达水平，并诱导疼痛相关行为。