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Gene expression and chromatin accessibility of iLSCs vs iBlasts cells

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https://www.ncbi.nlm.nih.gov/sra/SRP178505
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We identified two phenotypically and functionally distinct populations in AML-iPSC lines upon hematopoietic differentiation. A cell fraction with a hematopoietic stem cell (HSC) immunophenotype exhibiting adherent growth (iLSCs =samples A) and a fraction of more differentiated cells growing in suspension (iBlasts =samples S). We used RNA-seq and ATAC-seq analyses to identify molecular differences between the two populations. Overall design: Comparison of gene expression (RNA-seq) in genetically clonal iLSCs vs iBlasts
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2020-01-12
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