Crystal structure of RXR alpha LBD bound to a partial agonist 21 and a coactivator fragment SRC1

Crystal structure of RXR alpha LBD bound to a partial agonist 21 and a coactivator fragment SRC1 Descriptor: 3-[[4-cyclobutyl-6-(3,4-dihydro-2~{H}-quinolin-1-yl)pyrimidin-2-yl]amino]propanoic acid, Nuclear receptor coactivator 1, Retinoic acid receptor RXR-alpha Authors: Morozov, V, Merk, D, Lewandowski, M. Deposit date: 2025-08-01 Release date: 2025-10-29 Last modified: 2025-12-24 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural Tuning of Partial RXR Agonism and Antagonism. J.Med.Chem., 68, 2025