Global Burden of Disease Study (GBD) Alcohol Consumption and Ischemic Heart Disease Burden of Proof and Risk-Outcome Scores

Researchers systematically reviewed, identified, and extracted data from cohort, case-control, and Mendelian randomization studies published between 1970 and 2021 that estimated the association between alcohol consumption and risk of ischemic heart disease. In total, 124 unique studies were included. Relative risk curves for the association between alcohol consumption and ischemic heart disease were estimated using data from cohort and case-control studies separately and in combination, and from Mendelian randomization studies using the Burden of Proof meta-analytic framework.

研究人员对1970年至2021年间发表的、评估饮酒与缺血性心脏病风险关联的队列研究、病例对照研究及孟德尔随机化（Mendelian randomization）研究进行了系统回顾，并从中系统性地识别、提取相关数据。最终共纳入124项独立研究。研究人员分别基于队列研究、病例对照研究的单独数据及二者的合并数据，结合采用举证责任（Burden of Proof）元分析框架的孟德尔随机化研究数据，估算了饮酒与缺血性心脏病之间关联的相对风险曲线。

搜集汇总

背景与挑战

背景概述

该数据集通过系统综述1970-2021年间124项研究，使用Burden of Proof元分析框架评估酒精消费与缺血性心脏病的关联风险曲线。数据覆盖全球范围，由IHME于2024年发布，专注于酒精使用和缺血性心脏病风险因素的分析。