Brain transcriptomic analysis in Parkinson's disease patients stratified by Braak Lewy body stage / Sex differences in Parkinson's disease brain transcriptome

To investigate transcriptomic changes associated with Parkinson's disease development we compared frontal cortex gene expression across four Braak Lewy body stage groups. Additionally we investigated sex-specific gene expression differences in neuropathologically healthy donors and Parkinson's disease patients at Braak Lewy body stage 5. We investigated sex-specific gene expression differences in neuropathologically healthy donors and Parkinson's disease patients at Braak Lewy body stage 5. Overall design: Comparison of frontal cortex gene expression across Braak Lewy body stage groups (Braak Lewy body stage 0, 1-4, 5 and 6) Comparison of frontal cortex gene expression between males and females in neuropatholocially healthy donors (Braak Lewy body stage 0) and Parkinson's disease patients (Braak Lewy body stage 5)