Structure of CypD in complex with an inhibitor.
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Structure of CypD in complex with an inhibitor. Descriptor: 1-[(1~{S})-2-[2-(2-bromophenyl)pyrazolidin-1-yl]-2-oxidanylidene-1-phenyl-ethyl]-3-[[(1~{R},9~{R},10~{S})-10-oxidanyl-12-oxa-8-azatricyclo[7.3.1.0^{2,7}]trideca-2(7),3,5-trien-4-yl]methyl]urea, Peptidyl-prolyl cis-trans isomerase F, mitochondrial Authors: Zacharchenko, T, Antonyuk, S, Lian, L.Y. Deposit date: 2024-12-19 Release date: 2025-11-05 Last modified: 2025-12-17 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Potent Preorganized Pyrazolidine Cyclophilin D Inhibitors Prevent Mitochondrial and Organ Injury in a Mouse Pancreatitis Disease Model. J.Med.Chem., 68, 2025
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2024-12-19
