The antibody catalysis route to the total synthesis of epothilones
收藏PubMed Central1998-12-08 更新2026-05-02 收录
下载链接：
https://pmc.ncbi.nlm.nih.gov/articles/PMC24496/
下载链接
链接失效反馈官方服务：
资源简介：
An efficient monoclonal aldolase antibody that proceeds by an enamine mechanism was generated by reactive immunization. Here, this catalyst has been used in the total synthesis of epothilones A (1) and C (3). The starting materials for the synthesis of these molecules have been obtained by using antibody-catalyzed aldol and retro-aldol reactions. These precursors were then converted to epothilones A (1) and C (3) to complete the total synthesis.
提供机构：
National Academy of Sciences
创建时间：
1998-12-08
