Identification of Aurora B pathway involved in the anti-cancer effects by Paeoniae Radix extracts based on whole transcriptome analysis

we profiled the change in genome-wide gene expression of human lung cancer cells in response to treatment of water and ethanol extracts of PR and its ingredients in a dose dependent manner to investigate PR efficacy at the molecular pathway level. Overall design: Total whole transcritome profiles treated with water extract of Paeoniae Radix (PR), ethanol extract of PR, and eight ingredients in A 549 lung cancer cell lines.