Summary of the observed frequencies differences of co-morbid disorders between the GAIN and TGEN samples, as well as between the underlying family and bipolar singleton samples.

Key: Family refers to bipolar subjects ascertained through the collection of families for NIMH Waves 1–4. Singleton refers to bipolar subjects ascertained as singleton cases collected as part of Wave 5. Note: Significant differences in co-morbidity were not observed between bipolar subjects with irritable vs. elated mania in either sample, nor were differences observed for gender, age at interview, age at onset, age at first mania, or age at most severe mania for any comparison (i.e., irritable vs. elated mania, GAIN vs. TGEN, family vs. singleton, all p>0.10).