Management of Morphea with Topical Therapies: An Evidence-Based Review

Morphea, also known as localized scleroderma, is a rare inflammatory and sclerosing disease with cutaneous and extracutaneous manifestations. Topical therapies are often used alone or in combination with systemic and/or light therapies, depending on disease subtype, extent, and severity. This systematic review examines the use of topical therapies in morphea, with a focus on skin efficacy.

Morphea，亦称局限性硬皮病，是一种罕见且具有炎症性和纤维化的疾病，其临床表现包括皮肤和皮肤外症状。根据疾病的亚型、范围和严重程度，局部治疗常单独使用或与系统治疗和/或光疗联合应用。本次系统综述旨在探讨局部治疗在Morphea中的应用，重点关注其皮肤疗效。