Supplementary Material for: Less Fibrotic Burden Differently Affects the Long-Term Outcomes of Hepatocellular Carcinoma after Curative Resection

Background: The clinical features of hepatocellular carcinoma (HCC) differ in patients with and without cirrhosis. Objective: We aimed to investigate the long-term outcomes of noncirrhotic HCC patients after curative resection. Methods:
We retrospectively examined 649 consecutive patients with HCC who
underwent curative resection from 1996 to 2012; 387 (59.6%) were
cirrhotic and 262 (40.4%) were noncirrhotic. Results: The
mean age was 54.7 years, and 511 (78.7%) of the study participants were
men. The most common cause of HCC was hepatitis B virus (n = 419,
64.6%). Noncirrhotic tumors were larger and more advanced than
cirrhotic tumors. However, the noncirrhotic group showed better
disease-free survival (DFS) and overall survival (OS) after resection
than the cirrhotic group (median 64.0 vs. 56.0 months for OS and 48.0
vs. 31.0 months for DFS, p < 0.05). The predictors for HCC recurrence were cirrhosis, tumor number, portal vein invasion, and major surgery. Conclusions:
Noncirrhotic HCC showed better DFS and OS after resection than
cirrhotic HCC, although noncirrhotic HCC presented more aggressively.