Supplementary Material for: SMARCA4/SMARCA2 deficient undifferentiated metastatic malignant tumor with carcinoma of unknown primary case report

SMARCA4/SMARCA2 deficiencies have been linked to a variety of neoplasms and have been mainly described in cases of thoracic non-small cell lung cancers. Here we present a case of SMARCA4/SMARCA2 deficient undifferentiated metastatic malignant tumor with carcinoma of unknown primary origin. The staining on pathology as well as the unremarkable size of the lung masses raises the possibility of dedifferentiated tumor from unknown primary. This case highlights the need for more routine testing of this mutation as well as the development of more targeted therapies as these mutations are often associated with an aggressive course and poor outcomes.