Sensitivity analysis: Study deviated from HWE were excluded in Asians under all models and for overall studies in recessive model.

M, Statistical model.R, random-effects model; F, fixed-effects model.PZ, P value for Z test; PH, P value for heterogeneity.SA-A: Sensitivity analysis (Study deviated from HWE were exclude).in Asians.SA-O: Sensitivity analysis (Study deviated from HWE were exclude).in overall studies.*:the association is sill significant after Bonferronic correction for multiple testing.