Crystal structure of PRMT5:MEP50 in complex with MTA and TNG462
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Crystal structure of PRMT5:MEP50 in complex with MTA and TNG462 Descriptor: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ... Authors: Whittington, D.A. Deposit date: 2025-01-31 Release date: 2025-03-12 Last modified: 2025-03-19 Method: X-RAY DIFFRACTION (2.47 Å) Cite: Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with MTAP Deletion. J.Med.Chem., 68, 2025
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2025-01-31
