Effect of depletion of Rcrin on gene expression in mouse liver tissues

To investigate the function of Rcrin in liver, we established Rcrin flox mice and crossed with Alb-cre mice, then we generated Rcrin conditional knockout mice. Then we got liver tissues from Rcrin conditional knockout mice and Rcrin flox mice. We then performed gene expression profiling analysis using data obtained from RNA-seq of Rcrin conditional knockout mice (Rcrin knockout) and Rcrin flox mice (WT) at age of 8 weeks old. Comparative gene expression profiling analysis of RNA-seq data for liver tissues from Rcrin conditional knockout mice (Rcrin knockout) and Rcrin flox mice (WT).为探究Rcrin在肝脏中的生物学功能，我们构建了Rcrin flox小鼠（Rcrin flox mice），并将其与Alb-cre小鼠交配，成功获得Rcrin条件性基因敲除小鼠。随后，我们采集8周龄Rcrin条件性基因敲除小鼠（Rcrin敲除组）与Rcrin flox小鼠（野生型对照组，WT）的肝脏组织，基于二者的RNA测序（RNA-seq）数据开展基因表达谱分析，并针对两组小鼠肝脏组织的RNA-seq数据完成了对比基因表达谱分析。