The sequence information of BLR, C73, and HM26
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Unveiling the molecular mechanisms underlying rotavirus replication and pathogenesis had been hampered by the lack of a reverse genetics (RG) system in the past. Since 2017, multiple plasmid-based RG systems for simian, human, and murine-Like rotaviruses have been established. However, none of the described methods have supported the recovery of bovine rotaviruses (BRVs). Here, an optimized plasmid-based RG system for BRV culture-adapted strain (BRV G10P [15] BLR) and clinical isolates (BRV G6P[1] C73, G10P[11] HM26) was established based on a BHK-T7 cell clone stably expressing T7 polymerase.
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Science Data Bank
创建时间：
2024-08-23
