Celecoxib induced transcriptional alterations in gastric cancer cells. Homo sapiens

Celecoxib is recognized to have chemopreventive and anti-cancer property beyond its anti-inflammatory function. Celelcoxib treatment in AGS cells down regulates Wnt/β-catenin, STAT3, RXR and ERK/MAPK signaling pathways. Transcriptional profiling after celecoxib shows differential regulation of oncogenic pathway regulated genes. Overall design: AGS cell were treated with celecoxib in triplicates and incubated for 24 hours. The processed samples were hybridized in “HuGene-1_0-st” array and the differentially expressed genes were taken for pathway analysis and transcription factor enrichment analysis.