SUGAR study metadata

The current study investigates postprandial incretin hormone levels and their determinants using a standardized oral glucose tolerance test (OGTT) comparing non-diabetic patients with CKD and controls. We first describe the association of the presence and severity of kidney disease with circulating concentrations of incretin hormones in both fasted and postprandial states. We separately investigate the association of postprandial circulating incretin hormones with insulin, c-peptide, and glucagon levels during an OGTT by CKD status. We hypothesized that non-diabetic CKD is associated with reduced incretin hormone release and impaired glucagon suppression that contribute to glucometabolic complications underlying heightened cardiometabolic risk in CKD.