Influenza A virus strain:H5N1

Vaccines are useful tools to control influenza A virus infection in poultry, but they need to be periodically reformulated to guarantee appropriate protection from infection and to avoid viral replication and circulation, which could favour the emergence of new variants. In this study, a deep sequencing approach was used to characterize and follow the evolution of the hemagglutinin of H5N1 highly pathogenic avian influenza viral population in infected animals vaccinated with two vaccines conferring different protection levels.