Epigenetic determinants of self-renewal in glioblastoma
收藏官方服务：
资源简介：
Epigenetic determinants of self-renewal in glioblastoma
应用场景：
创建时间：
2015-11-11
相关数据集
Additional file 8 of Ten-eleven translocation protein 1 modulates medulloblastoma progression
Additional file 8: Table S7. Summary of 5hmC gain and loss regions in SmoA1-MBs.
Figshare2024-02-20 更新70
DNA methylome evolution and reprogramming in recurrent glioblastoma
Recurrent glioblastoma (GBM) has a grim prognosis, though MGMT promoter methylation and IDH mutation provide a significant survival advantage. The product of IDH mutation, 2-hydroxyglutarate, increas
NIAID Data Ecosystem60
Differential gene expression of neuroblastoma cells stably expressing doxycycline-inducible DOT1L small hairpin RNA. Homo sapiens
We were interested in studying the role of DOT1L-mediated H3K79 methylation on N-Myc target gene transcription in MYCN-induced neuroblastoma. We aimed to determine whether knocking down DOT1L in MYCN-
NIAID Data Ecosystem30
MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin [expression]
Mutations in the histone 3 variant H3.3 have been identified in one-third of pediatric glioblastomas (GBMs), but not in adult tumors. Here we show that H3.3 is a dynamic determinant of functional prop
NIAID Data Ecosystem60
EGFR Mutation Promotes Glioblastoma Through Epigenome and Transcription Factor Network Remodeling
Epidermal Growth Factor Receptor (EGFR) gene amplification and mutations are the most common oncogenic events in Glioblastoma (GBM), but the mechanisms by which they promote aggressive tumor growth ar
NIAID Data Ecosystem30
