Plakophilin-2 (PKP2) is classically defined as a component of the desmosome. Besides its role in cell–cell adhesion, PKP2 can modulate transcription through intracellular signals initiated at the site

NIAID Data Ecosystem50

Gene expression profiling of hypertrophic and failing cardiomyocytes identifies new players in heart failure. Gene expression profiling of hypertrophic and failing cardiomyocytes identifies new players in heart failure

心力衰竭基因表达

心肌细胞转录组学

Aim - Pathological cardiac remodeling is characterized by cardiomyocyte hypertrophy and fibroblast activation, which can ultimately lead to heart failure (HF). Genome-wide expression analysis on heart

NIAID Data Ecosystem40

RNA-Seq of Ctrl, Myocd KO, Mrtfa/b DKO and TKO cardiomyocytes

心肌细胞转录组学

基因敲除功能研究

To characterize transcriptome changes uopn Myocd KO, Mrtfa/b DKO and Mrtfa/b/Myocd TKO in maturing cardiomyocytes AAV-Cre or AAV-Myocd-sgRNAwere injected into P1 Rosa-Cas9GFP or Mrfta-/-; Mrtfb-F/F;

NIAID Data Ecosystem70

RNA-Seq of Ctrl, Myocd KO, Mrtfa/b DKO and TKO cardiomyocytes

心肌细胞转录组学

基因敲除模型

To characterize transcriptome changes uopn Myocd KO, Mrtfa/b DKO and Mrtfa/b/Myocd TKO in maturing cardiomyocytes Overall design: AAV-Cre or AAV-Myocd-sgRNAwere injected into P1 Rosa-Cas9GFP or Mrfta

NIAID Data Ecosystem40

Transcription profiling of rat neonatal cardiomyocytes treated with corticosteroid

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