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Transcriptome changes in human endothelial cells with constitutively active YAP, TAZ and TEAD mutants

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https://www.ncbi.nlm.nih.gov/sra/SRP298391
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资源简介:
Transcriptome profiling of human umbilical vein endothelial cells (HUVECs) overexpressing constitutively nuclear YAP (YAP S127A), TAZ (TAZ S89A) or TEAD-binding deficient YAP (YAP S94A/S127A) or TAZ (TAZ S51A/S89A) to identify YAP and TAZ target genes. Overall design: Analysis of HUVECs transduced with a lentivirus encoding for a nuclear YAP and TAZ mutant compared to HUVECs transduced with a control lentivirus (Ctrl). Expression analysis was performed 48h post doxycycline induction.
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2022-07-08
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