Acute muscle damage activates miRNA machinery in isolated myofibers.

Dystrophic-fibres associated miRNAs were quantified by Q-PCR in single fibres isolated from TA of c57bl mice (n = 10) after CTX-injection. Mice were sacrified at the day 2, 5, 7, 10 after CTX-injury. In the table are represented the fold change values of tested miRNAs in CTX-injected muscle compare to controlateral not injected TA. MiR-206, miR-31, miR-21, miR-335-5p, miR-27a, miR-142-5p and miR-223 were significantly up-regulated afterwards muscle damage respect damaged muscle. Otherwise the other 7 miRNAs were not triggered upon CTX-injection.
(Two-tail parametric t-test; *p value <0, 05; **p value <0, 01; ***p value <0,001).