Dynamic trend of neutralizing antibody GMTs (95%CI) for EV71 FCP-As.

Female BALB/c mice (4–6 weeks old) were i.p. inoculated with three EV71 FCP-As (V1, V2, and V3) containing 200 U antigen. The sera were isolated and tested at 7, 14, 21, 28, 56 and 84 d post-inoculation. NAb titers equal to and above 1∶1536 were assigned a value of 1∶1536. Common logarithmic transformation of the NAb titer raw data was used to calculate the GMT and CV. SPSS10.0 software was used for statistical analyses.*Denotes a significantly higher NAb GMT for V1 at 84 d post- inoculation than that of V1 at 14 d, 21 d and 28 d post-inoculation (P.**Denotes a significantly higher NAb GMT for V2 at 84 d post- inoculation than that of V2 at 7 d, 14 d and 21 d post-inoculation (P.***Denotes a significantly higher NAb GMT for V3 at 84 d post- inoculation than that of V3 at 21 d, 28 d and 56 d post-inoculation (P.