Absence of the eisosome causes general transcriptome remodeling of the yeast cell

We investigated the effect of the absence of the eisosome on the overall yeast transcriptome by gene expression profiling analysis. We used data obtained from RNA-seq (polyA enrichment of total RNA isolates) of 3 different strains, specifically wild type (BY4742), a strain missing PIL1 gene that forms eisosome remanants instead of eisosome and our newly described seg1Δnce102Δpil1Δ strain, which forms neither eisosomes, nor eisosome remnants, even in the response to stress. Comparative gene expression profiling analysis of RNA-seq data for wild type (BY4742), pil1Δ and seg1Δnce102Δpil1Δ cells grown in SC for 24 hours.