Decline of Nucleotide Excision Repair Capacity in Aged Caenorhabditis elegans
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We used gene expression profiling to address several specific questions that arose in a study of repair of ultraviolet C radiation in C elegans, as well as to generate hypotheses regarding the possible mechanism(s) of decreased DNA repair observed in old adults in that study. This analysis was performed in order to analyze gene expression in the strain (JK1107) and experimental conditions that we used for our DNA repair studies. The supplementary file GSE4766_Resolver_all_data.txt includes Resolver generated fold-changes and p values based on ratios built in Rosetta Resolver as described in the Rosetta Biosoftware Technical Note (Lee Weng, 2004), Data processing and analysis methods in the Rosetta Resolver system (http:
本研究采用基因表达谱分析技术，旨在解答秀丽隐杆线虫（C. elegans）紫外线C辐射修复相关研究中提出的若干特定问题，同时针对该研究中观察到的老年个体DNA修复能力下降现象，提出其潜在作用机制假说。本次分析的目标为解析我们在DNA修复研究中所使用的品系（JK1107）及对应实验条件下的基因表达水平。补充文件GSE4766_Resolver_all_data.txt包含由Rosetta Resolver生成的倍数变化值与p值，该类数据基于Rosetta Resolver内置的比值计算得到，具体方法详见《Rosetta生物软件技术说明》（Lee Weng, 2004）及《Rosetta Resolver系统数据处理与分析方法》（http:
