Identification of small noncoding RNAs as sperm quality biomarkers for in vitro fertilization. Identification of small noncoding RNAs as sperm quality biomarkers for in vitro fertilization

We investigated differentially expressed sncRNAs in human sperm as candidate markers for evaluating sperm quality during IVF. We demonstrated that differentially expressed tsRNAs, rsRNAs and miRNAs are linked to sperm quality according to embryo quality, even though these sperm samples were all considered normal by the traditional semen-parameter assessment. Therefore, the sncRNAs, especially tsRNAs and rsRNAs, may be potential clinical biomarkers for the assessment of sperm quality in IVF. Overall design: We performed small noncoding RNA profiling for 87 human sperm samples by deep sequencing