Clariom S mouse arrays of C57Bl6/NTac mice to analyse how obesogenic diet exposure of parents induces sex-specific programming of overweight in mouse offspring

The arrays were used to explore how parents' obesity status influence their offspring's weight. We randomly assigned three-week-old mice to two groups, one group receiving a high-fat diet (HFD), the other group receiving a control diet (chow). Adult females of both groups were mated to males fed with HFD or CD. F1 transcriptome assay data were created from four tissues (liver, epigonal visceral, inguinal subcutaneous, and interscapular brown adipose tissue) of male offspring in relation to their parents' obesity status.本研究采用基因芯片阵列（arrays）探究双亲肥胖状态对子代体重的影响。我们将三周龄小鼠随机分为两组，一组饲喂高脂饮食（high-fat diet, HFD），另一组饲喂对照饲料（chow）。将两组的成年雌性小鼠与饲喂高脂饮食（HFD）或对照饮食（CD）的雄性小鼠交配后，针对与双亲肥胖状态相关的雄性子一代小鼠，采集其肝脏、附睾旁内脏脂肪、腹股沟皮下脂肪及肩胛间棕色脂肪组织四种组织的样本，制备得到F1转录组检测数据。