Feasibility and acceptability of personalized breast cancer screening (DECIDO Study): A single-arm proof-of-concept trial

The aim of this study was to assess the acceptability and feasibility of
offering risk-based breast cancer screening and its integration into
regular clinical practice. A single-arm proof-of-concept trial was
conducted with a sample of 387 women aged 40–50 years residing in the city
of Lleida (Spain). The study intervention consisted of breast cancer risk
estimation, risk communication and screening recommendations, and a
follow-up. A polygenic risk score with 83 single nucleotide polymorphisms
was used to update the Breast Cancer Surveillance Consortium risk model
and estimate the 5-year absolute risk of breast cancer. The women
expressed a positive attitude towards varying the frequency of breast
screening according to individual risk and, especially, more frequently
inviting women at higher-than-average risk. A lower intensity screening
for women at lower risk was not as welcome, although half of the
participants would accept it. Knowledge of the benefits and harms of
breast screening was low, especially with regard to false positives and
overdiagnosis. The women expressed a high understanding of individual risk
and screening recommendations. The participants’ intention to participate
in risk-based screening and satisfaction at 1-year were very high.