Bifacial Nucleoside as a Surrogate for Both T and A in Duplex DNA
收藏NIAID Data Ecosystem2026-03-07 收录
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A new functional bifacial nucleoside derived from 7-aminopyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione, a Janus-type nucleobase, has been synthesized and incorporated into DNA oligonucleotides. The nucleobase, having self-complementary H-bonding faces, mimics both T and A and engages in the corresponding Watson–Crick-like base pairs, forming stable duplexes.
创建时间：
2011-05-11
