Targeted high resolution array comparative genomic hybridization of the 4p16.3 locus in seven glioblastoma patients Overall design: A custom Agilent CGH microarray based on the 105A backbone was desig
The first event in origination of many childhood leukemias is likely the presence of preleukemic clone (transformed hematopoietic stem/progenitor cells with preleukemic gene fusions (PGF)) in newborn.
Testing library production. Genomic libraries (500 bps) will be generated from total genomic DNA derived from commomon epithelial cancer samples and subjected to paired end sequencing on the llumina
aGene fusions initially nominated by breakpoint analysis and subsequently validated by paired-end RNA-seq (or 5′ RACE for CEP85L/ROS1) and RT-PCR.bABL1 and EGFR locus rearrangements were previously re