Tgif1 regulates quiescence and self-renewal signaling pathways of hematopoietic stem cells (HSCs)

ChEBI2013-09-10 更新2026-07-21 收录

造血干细胞调控

分子信号通路

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Tgif1 regulates quiescence and self-renewal signaling pathways of hematopoietic stem cells (HSCs)

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2013-09-10

High-throughput single cell gene expression analysis in primary blood stem and progenitor cells identifies new links between key transcriptional regulators. Mus musculus

单细胞转录组学

造血干细胞调控

Cellular decision-making is mediated by a complex interplay of external stimuli with the intracellular environment, in particular transcription factor regulatory networks. Here we have determined the

NIAID Data Ecosystem80

Arid1a-Plagl1-Hh signaling is indispensable for differentiation-associated cell cycle arrest of tooth root progenitors [ATAC-Seq]. Arid1a-Plagl1-Hh signaling is indispensable for differentiation-associated cell cycle arrest of tooth root progenitors [ATAC-Seq]

分子信号通路

牙齿发育

We show that loss of Arid1a impairs the differentiation-associated cell cycle arrest of tooth root progenitors through Hh signaling regulation, leading to shortened roots. Our data suggest that Plagl1

NIAID Data Ecosystem40

Eif3d safeguards the homeostasis of Key signaling pathways in Human primed pluripotency

干细胞生物学

分子信号通路

Although pluripotent stem cell (PSC) properties, such as differentiation and infinite proliferation, have been well documented within the frameworks of transcription factor networks, epigenomes, and

DataCite Commons2025-04-01 更新30

ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation

造血干细胞调控

转录因子功能分析

To investigate the role of the transcription factor ERG in hematopoiesis we generated Erg heterozygous knockout and conditional Erg knockout mice. We found that several hematopoietic cell types were d

NIAID Data Ecosystem60

Gene expression profile of HSCs from Angptl2fl/fl or Cdh5-Cre;Angptl2fl/fl mice

造血干细胞调控

内皮细胞-干细胞信号转导

To identify the intracellular targets of endothelial cell-specific ANGPTL2 that control HSC stemness, HSCs from Angptl2fl/fl or Cdh5-Cre;Angptl2fl/fl were sorted, followed by the extraction of total

NIAID Data Ecosystem40

Tgif1 regulates quiescence and self-renewal signaling pathways of hematopoietic stem cells (HSCs)

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