Transcriptomics of THP-1 host cells infected with Mycobacterium tuberculosis (Mtb)

Infection is a dialog between the pathogen and the host. Understanding the molecular basis of infection requires understanding the responses and adaptations of both the pathogen and host as a consequence of this dialog. We studied Mtb infection in human THP-1 cells by transcriptomics profiling of host expression over the course of an acute to anestablished infection. TbSysBio (National Institute of Allergy and Infectious Diseases, National Institute of Health) Microarray experiments were performed as single-color hybridizations using Agilent Technologies whole human genome 4x44K microarrays