SnAP-eX Reagents for the Synthesis of Exocyclic 3‑Amino- and 3‑Alkoxypyrrolidines and Piperidines from Aldehydes

SnAP-eX (tin amine
protocol, exocyclic heteroatoms) reagents allow
the single-step transformation of aldehydes and ketones into 2,3-disubstituted
pyrrolidines and piperidines containing exocyclic amine or alkoxy
groups. These saturated N-heterocycles are of importance in modern
drug discovery approaches and are prepared in moderate yields using
an operationally simple protocol that is compatible with a range of
functional groups and heterocyclic aldehydes.