Mitochondria-targeted antioxidant Mitotempo mitigates Aβ-induced mitochondrial superoxide production and apoptotic neuronal death.

(A1) Aβ, OGD or their combination induced significantly increased mitochondrial superoxide production which was marked attenuated by the application of Mitotempo. (A2) Representative images of MitoSox Red (Red) and mitotracker green (Green). Scale bar = 50μm. (B1) Aβ, OGD or their combination induced significantly increased apoptotic neuronal death which was marked attenuated by the application of Mitotempo. (B2) Representative images of TUNEL staining. Scale bar = 100μm. *P<0.05 and **P<0.01. # P<0.01 vs all the other groups.