Characteristics of Underlying Trials.

BID – twice daily; DB = double blind; ITT = Intention to Treat; MI = Myocardial Infarction; N = Population of Study; OL = Open Label; R = Randomized Trial; TTR = Time in Therapeutic Range.aDouble-blinding was used in RE-LY, but only for the dabigatran arms. Since the corresponding Markov model compared the cost-effectiveness of dabigatran (both doses) to warfarin, we report this trial as “open-label” above;bDifference between rate of major or clinically relevant nonmajor bleeds and major bleeds.cDifference between reported any bleed and reported major bleed rates;‡Stroke or systemic embolism;