Comparative analysis of liver mitochondrial ncRNA in metabolic disease model mice.

ncRNA has been shown to be important for various biological processes including transcriptional regulation and protein complex formation. Mitochondoria were purified from the livers of normal mice and three metabolic model mice, and the RNA contained therein was analyzed by the next-generation sequencing method. Differential expression patterns of RNA species were detected in normal and three models, and some ncRNA were significantly up- or down-regulated in the metabolic models. Examination of liver mitochondrial ncRNA species in metabolic disease model mice.