Management recommendations for clinically significant CNVs and recommendation according to the level of evidence.

Abbreviations: MCA = Multiple Congenital Anomalies; DD = Developmental Delay; ASD = Autism Spectrum Disorders; Dys = Dysmorphism; UCS = Uncertain Clinical Significance. Abbreviations: S = Surveillance; R = specialist Referral/assessment; D = Diagnostic testing; P = medical/surgical Procedure; M = Medication administration; L = Lifestyle recommendation; O = Other interventions. * = pathogenic CNVs, ∧ = likely pathogenic CNVs. N = not tested; Mat = maternal inheritance; Pat = paternal inheritance. Management recommendations for clinically significant CNVs and recommendation according to the level of evidence.