Cleaned dataset for PubChem AID 720719: qHTS assay of glucocorticoid receptor (GR) agonists

This dataset is derived from PubChem BioAssay AID 720719, titled "qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway". The original assay is part of the Tox21 program and measures activation of glucocorticoid receptor (GR) signaling using a beta-lactamase reporter assay in mammalian cells expressing a GR-responsive reporter system. Original dataset statistics: - Tested compounds: 8,099 - Active (agonists): 180 - Inactive: 7,201 Data preprocessing: - Removed duplicate entries based on compound identifiers. - Resolved conflicting labels by excluding compounds with inconsistent activity annotations. Final cleaned dataset: - Total compounds: 7,188 - Positive (agonists): 156 - Negative (inactive): 7,032