Asymmetric Total Synthesis of (−)-Spirochensilide A
收藏NIAID Data Ecosystem2026-03-11 收录
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资源简介：
An asymmetric total synthesis of (−)-spirochensilide A has been achieved for the first time. The synthesis features a semipinacol rearrangement reaction to stereoselectively construct the two-vicinal quaternary chiral centers at C8 and C10, a tungsten-mediated cyclopropene-based Pauson–Khand reaction to install the C13 quaternary chiral center, and a furan-based oxidative cyclization to stereoselectively form the spiroketal motif.
创建时间：
2020-04-14
