Effect of neonatal right ventricular pressure overload on gene expression and regions of open chromatin during postnatal heart development

To investigate the effect of pressure overload (PO) during postnatal right ventricular (RV) development, we established the RV PO model by conducting pulmonary artery banding (PAB) surgery on neonatal Sprague-Dawley (SD) rats. We then performed gene expression and chromatin openness profiling analysis using data obtained from RNA-seq and ATAC-seq of RV free walls from PO and sham-operated rats at postnatal day 21 (P21). Overall design: Comparative gene expression and chromatin openness profiling analysis of RNA-seq and ATAC-seq data for right ventricular free wall myocardium in pressure overload and sham-operated Sprague-Dawley (SD) rats on postnatal day21.