Thyroid hormones and glucocorticoids crosstalks in Xenopus tropicalis liver at metamorphosis

Thyroid hormones (TH) and glucocorticoids (GC) are involved in numerous developmental and physiological processes. The effects of individual hormones are well documented, but little is known about the actions of the two hormones jointly. To decipher the crosstalk between these two hormonal pathways, we have conducted a transcriptional analysis of genes regulated by TH, GC, or both hormones together in liver of Xenopus tropicalis tadpoles using RNA-Seq. A significant fraction of genes show non-trival regulatory response indicative of crosstalk between the two hormones. Reconstruction and analysis of biological network revealed that crosstalks target a subnetwork involved in the G2/M transition, suggesting a strong involvement in cell cycle regulation.