Gut microbiome communication with the bone marrow regulates intestinal inflammation and susceptibility to amebiasis.

We discovered that colonization of the gut with the human bile acid 7'-dehydroxylating bacteria Clostridia scindens provided immunity to the parasite E. histolytica in a murine model, increased granulocyte monocyte progenitors, and that adoptive marrow transplant from C. scindens colonized mice into naive mice could recapitualte this protection. Overall design: RNA-seq in granulocyte monocyte progenitors