Follicular microbiome response to isotretinoin treatment

There are no drugs as effective as isotretinoin for acne. Deciphering the changes in the microbiome induced by isotretinoin in the pilosebaceous follicle of successfully treated patients can pave the way to identify novel therapeutic alternatives. To determine how the follicular microbiome changes with isotretinoin, and to identify which alterations correlate with a successful treatment response, we performed whole genome sequencing on casts from facial follicles of acne patients sampled before, during, and after isotretinoin treatment.