Lymphangioleiomyomatosis (LAM) is a progressive cystic lung disease caused by tuberous sclerosis complex 1/2 (TSC1/2) gene mutations resulting in activation of the mechanistic target of rapamycin comp

Alliance of Genome Resources30

Smooth muscle-derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis. Smooth muscle-derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis

肺血管重塑

成纤维细胞分化

Resident vascular adventitial SCA1(+) progenitor (AdvSca1) cells are essential in vascular development and injury. However, the heterogeneity of AdvSca1 cells presents a unique challenge in understand

NIAID Data Ecosystem20

Expression data from lungs of rats with pulmonary hypertension

肺动脉高压基因表达

肺血管重塑

Pulmonary hypertension is a frequent consequence of left heart disease and congestive heart failure (CHF) and causes extensive lung vascular remodelling which leads to right ventricular failure. Funct

NIAID Data Ecosystem70

Data_Sheet_1_Sotatercept analog improves cardiopulmonary remodeling and pulmonary hypertension in experimental left heart failure.pdf

肺动脉高压治疗

肺血管重塑

Pulmonary hypertension due to left heart disease (PH-LHD) is the most frequent manifestation of PH but lacks any approved treatment. Activin receptor type IIA-Fc fusion protein (ActRIIA-Fc) was found

NIAID Data Ecosystem30

Supplementary Information S1 - Rule-Based Model of Vein Graft Remodeling

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