The oral microbiome of a family including Papillon-Lefevre-Syndrome patients and clinically healthy members

AimsThe oral microbiota composition of patients diagnosed with Papillon-Lefevre syndrome and treated for several years were compared to those existing in the oral cavity of the clinically healthy family members and a cohort of patients having various stages of chronic periodontitis.Materials and methodsA family with two sisters affected with severe periodontitis and with the typical skin symptoms of Papillon-Lefevre syndrome, and symptomless parents and thirdsibling were investigated. The Patients received periodontal treatment for several years and their oral microbiome was analysed by amplicon sequencing. Data were evaluated by microbial cluster analysis.ResultsThe microbiome of the patients with Papillon-Lefevre syndrome was predominatedwith Aggregatibacter actinomycetemcomitans and associated oral periodontopathogens. Although the clinically healthy family members showed no oral disorder, their microbiome resembled that of subjects having mild periodontitis.ConclusionsPredominance of A. actinomycetemcomitans in the subgingival microbiome of patients with Papillon-Lefevre-syndrome suggests that specific treatment strategies directed against this pathobiont may improve the oral health status of the affected individuals.